Linked Life Data

7929907

Source:http://linkedlifedata.com/resource/pubmed/id/7929907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-10-27
pubmed:abstractText
The spatiotemporal distribution of cell death in the chick embryo neural tube and spinal cord (brachial region) was examined between stage (St.) 12 and 22, in plastic semithin sections. Between St. 12 and 16, the total number of pycnotic cells per segment was low, whereas after St. 16 the number of pycnotic cells was substantially increased. Between St. 17 and 19 three cell death foci or regions could be recognized. One region, the dorsal pycnotic zone, was located in the most dorsal part of the spinal cord, including the neural crest, with the highest number of pycnotic cells observed at St. 18. The second region, or ventral pycnotic zone, was located between motoneurons and the floor plate and had the highest number of dying cells at St. 17. The third region, the floor plate pycnotic zone, was located in the midportion of the floor plate and had the greatest amount of cell death at St. 19. Although low numbers of pycnotic cells were also observed in other regions between St. 17 and 19, no pycnotic cells were found in the ventrolateral region that gives rise to motoneurons. Ultrastructural observations as well as data from in situ nick end labeling indicate that the pycnotic cells observed in the neural tube die by apoptosis and that the debris from the dead cells is phagocytized primarily by adjacent healthy neuroepithelial cells. Although the spatiotemporal distribution of pycnotic cells suggests that cell death at these early stages could play a role in establishing the pioneer axonal pathway for spinal commissural neurons, preliminary observations following perturbations of cell death do not support this notion. Alternatively, early cell death may be involved in the regulation of cellular patterning along the dorsoventral axis of the neural tube by a kind of negative selection of specific progenitor cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
345
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-95
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Programmed cell death during the earliest stages of spinal cord development in the chick embryo: a possible means of early phenotypic selection.
pubmed:affiliation
Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina 27157-1010.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.