|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0037083,
umls-concept:C0205042,
umls-concept:C0205217,
umls-concept:C0205349,
umls-concept:C0332120,
umls-concept:C0857121,
umls-concept:C1135918,
umls-concept:C1140999,
umls-concept:C1325847,
umls-concept:C1522318
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1994-11-10
|
|
pubmed:abstractText |
The Ca2+ responsiveness of vascular smooth muscle myofilaments is not unique: it is increased during neuro-humoral activation and decreased during beta-adrenergic stimulation. In this study we tested whether an augmented Ca2+ responsiveness of smooth muscle myofilaments may contribute to the increased coronary tone observed in hypertension using beta-escin-permeabilized coronary arteries from 3-mo-old stroke-prone spontaneously hypertensive rats (SHRSP) and their age matched normotensive reference strain (WKY rats). In intact coronary arteries, the response to 5-hydroxytryptamine (5-HT) but not to KCl was larger in SHRSP than in WKY rats. In beta-escin permeabilized coronary arteries in which the receptor effector coupling is still intact, 5-HT enhanced force at constant submaximal (Ca2+) (pCa 6.38) to a greater extent in SHRSP. The Ca2+ sensitizing effect of 5-HT was mimicked by GTP gamma S (0.01-10 microM); again this effect was larger in SHRSP. In the absence of 5-HT or GTP gamma S the Ca2+ force relation was similar in both groups. Forskolin induced relaxation at constant submaximal (Ca2+). This desensitizing effect was smaller in SHRSP than in WKY rats. In conclusion, this study shows that intracellular signalling pathways involved in modulating the Ca2+ responsiveness of coronary smooth muscle myofilaments are altered in the genetically hypertensive animals favoring a hypercontractile state in the coronary circulation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1311501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1328235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1331069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1371463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1386078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-13896012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1415520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1473556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1518549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1558185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1568759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1577714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1656467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1657441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1848125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-1899969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2127310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2289529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2316638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2355955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2375416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2440425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2454609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2457080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2506180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2509451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2524524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2674422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2849434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-2983064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3159469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3277398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3465915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3477639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3891049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3945163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-3971514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-4059032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-4093883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-489574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6096534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6156384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6621711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6822294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6824790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-6858705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-7379260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-7470763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-8265963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-8327461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-8390503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-8423226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929815-8508922
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
94
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1397-403
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
|
