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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-11-7
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pubmed:abstractText |
Cell-matrix interactions are assumed to be important in regulating differentiation and tumor cell growth; however, the precise roles of individual matrix receptors in producing cellular responses are still unclear. We have previously described the alpha v beta 6 integrin, an epithelial cell fibronectin receptor expressed in many carcinoma cell lines. Here we show that heterologous expression of alpha v beta 6 in a human colon carcinoma cell line (SW480) enhances the proliferative capacity of these cells, both in vitro and in vivo in nude mice. This property of alpha v beta 6 correlates with the presence of an 11-amino acid region at the COOH terminus of the beta 6 cytoplasmic domain. This 11-amino acid sequence is required for the growth stimulatory effect, but not for other functions of the beta 6 cytoplasmic domain, such as promoting cell adhesion and focal contact localization.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1376331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1376731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1379699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1385446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1429685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1464591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1532572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1555235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-1825619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2116421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2150333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2155708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2208139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2392682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2460263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-2752160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-3407940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-7694284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-8081887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-8120056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-8245410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-8389464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7929593-903179
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-9525
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
127
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
547-56
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7929593-Amino Acid Sequence,
pubmed-meshheading:7929593-Animals,
pubmed-meshheading:7929593-Antigens, Neoplasm,
pubmed-meshheading:7929593-Cell Adhesion,
pubmed-meshheading:7929593-Cell Division,
pubmed-meshheading:7929593-Cell Line,
pubmed-meshheading:7929593-Collagen,
pubmed-meshheading:7929593-Colonic Neoplasms,
pubmed-meshheading:7929593-Fibronectins,
pubmed-meshheading:7929593-Humans,
pubmed-meshheading:7929593-Integrins,
pubmed-meshheading:7929593-Mice,
pubmed-meshheading:7929593-Mice, Nude,
pubmed-meshheading:7929593-Molecular Sequence Data,
pubmed-meshheading:7929593-Receptors, Fibronectin,
pubmed-meshheading:7929593-Transfection,
pubmed-meshheading:7929593-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.
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pubmed:affiliation |
Department of Medicine, University of California, San Francisco.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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