|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0014834,
umls-concept:C0018270,
umls-concept:C0034272,
umls-concept:C0042890,
umls-concept:C0087162,
umls-concept:C0301713,
umls-concept:C0596988,
umls-concept:C0814810,
umls-concept:C1152029,
umls-concept:C1546857
|
|
pubmed:issue |
19
|
|
pubmed:dateCreated |
1994-10-28
|
|
pubmed:abstractText |
We show that a tktA tktB double mutant, which is devoid of the two known transketolase isoenzymes of Escherichia coli K-12, requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth. This pyridoxine requirement can also be satisfied by 4-hydroxy-L-threonine or glycolaldehyde. These results provide direct evidence that D-erythrose-4-phosphate is a precursor of the pyridine ring of pyridoxine. In addition, they show that the two major E. coli transketolase isoenzymes are not required for the biosynthesis of D-1-deoxyxylulose, which is thought to be another precursor of pyridoxine.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-1100639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-1356963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-1537800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-2121717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-2681152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-4597996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-4902809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-4905534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-6987231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-7916691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-8226984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-8396116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7928977-8440369
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0021-9193
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
176
|
|
pubmed:geneSymbol |
tktA,
tktB
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6134-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth.
|
|
pubmed:affiliation |
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston 77030-1501.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
