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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-11-3
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pubmed:abstractText |
Thirty-two dogs with hyperadrenocorticism caused by cortisol-secreting adrenocortical neoplasia were treated with mitotane at an initial daily induction dosage of 27.5 to 75.0 mg/kg of body weight (mean, 46.3 mg/kg) for 10 to 14 days. All dogs received daily maintenance glucocorticoid supplementation during the induction period. After 2 weeks, the ACTH-stimulated serum cortisol concentration had decreased to within or below the reference range for baseline cortisol concentration in 18 (56.3%) of the 32 dogs; the remaining 14 (43.7%) still responded to ACTH administration with serum cortisol concentrations above the reference range. In these 14 dogs, mitotane was continued at a higher daily dosage (mean, 60.7 mg/kg) for an additional 1 to 9 weeks. Serum cortisol concentration subsequently fell within or below the reference range for baseline cortisol concentration in all but 1 dog. In 30 of the 32 dogs, mitotane was continued at an initial mean maintenance dosage of 101.6 mg/kg/wk, divided into 2 to 5 doses. Twenty-two dogs received prednisone daily (0.2 mg/kg) throughout the maintenance period. One or more relapses occurred in 19 (63%) of the 30 dogs. In dogs with relapse, the mean maintenance mitotane dosage was increased from 98.1 mg/kg/wk to a high of 212.4 mg/kg/wk. After a mean maintenance treatment time of 13.2 months, final mean maintenance dosage required in the 30 dogs ranged from 35.3 to 1,273 mg/kg/wk. Adverse effects were seen in 19 (59.4%) of the 32 dogs as a result of a drug toxicosis associated with high-dosage administration of mitotane, low serum cortisol concentration, or both.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:commentsCorrections | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-1488
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
205
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7928549-Addison Disease,
pubmed-meshheading:7928549-Adrenal Cortex Neoplasms,
pubmed-meshheading:7928549-Adrenocortical Hyperfunction,
pubmed-meshheading:7928549-Adrenocorticotropic Hormone,
pubmed-meshheading:7928549-Animals,
pubmed-meshheading:7928549-Dog Diseases,
pubmed-meshheading:7928549-Dogs,
pubmed-meshheading:7928549-Drug Therapy, Combination,
pubmed-meshheading:7928549-Female,
pubmed-meshheading:7928549-Follow-Up Studies,
pubmed-meshheading:7928549-Glucocorticoids,
pubmed-meshheading:7928549-Hydrocortisone,
pubmed-meshheading:7928549-Male,
pubmed-meshheading:7928549-Mitotane,
pubmed-meshheading:7928549-Remission Induction,
pubmed-meshheading:7928549-Treatment Outcome
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pubmed:year |
1994
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pubmed:articleTitle |
Mitotane treatment of 32 dogs with cortisol-secreting adrenocortical neoplasms.
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pubmed:affiliation |
Department of Environmental Studies, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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