Linked Life Data

7927861

Source:http://linkedlifedata.com/resource/pubmed/id/7927861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-11-18
pubmed:abstractText
Two problems appear when it is desired to get good knowledge concerning transfer of matter through a material, and especially the penetration of antibiotics into vegetations on heart valves. One is to build a numerical model to describe and simulate the process and thus to gain a fuller insight into the nature of the transfer. The other is to develop an in vitro test to represent the in vivo process, with simple operational conditions and accurate measurements. The in vitro test must enable one to measure the parameters of interest, i.e. the diffusivity of antibiotic through the vegetation, or rather through the blood located in the vegetation. Experiments and calculations are made in order to build a numerical model describing the process and to develop an in vitro test capable of determining the diffusivity. A simulation is made with a polymer bead made of Ethylene vinyl acetate saturated by a liquid such as n-heptane with a slight amount of benzene. The release of benzene from the polymer bead into n-heptane free from benzene is the best way for measuring the diffusivity of the benzene (simulating the antibiotic) through the liquid located in the polymer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0020-7101
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-75
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Intravegetation antimicrobial distribution in endocarditis: a numerical model and establishment of the conditions for an in-vitro test.
pubmed:affiliation
Laboratory of Materials and Chemical Engng., Faculty of Sciences, University of St. Etienne, France.
pubmed:publicationType
Journal Article