| pubmed-article:7927506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7927506 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7927506 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:7927506 | lifeskim:mentions | umls-concept:C0086983 | lld:lifeskim |
| pubmed-article:7927506 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7927506 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7927506 | pubmed:dateCreated | 1994-10-21 | lld:pubmed |
| pubmed-article:7927506 | pubmed:abstractText | Silica (SiO2) or related substances such as silicone ([-R2Si-O-]n), which is used in plastic surgery, or asbestos (e.g. chrysotile; 3MgO.2SiO2.H2O) have 'adjuvant effects'. In a study of scleroderma patients in Germany more than 78% had experienced exposure to silicate dust. T-cell receptor (TcR) V beta gene analysis on CD4- CD8- double-negative alpha beta T cells from scleroderma patients, using polymerase chain reaction (PCR), showed that certain V beta genes, V beta 5, V beta 7 and V beta 17, were predominantly expressed in the cells. We found that certain V beta repertoires, V beta 5.3 and V beta 6.7, were predominantly expressed on fractionated T cells with a high Ca2+ level that had been stimulated by chrysotile in vitro. The intracellular Ca2+ level in human peripheral blood mononuclear cells (PBMC) increased after incubation with silica or chrysotile. Interleukin-2 (IL-2) release from PMBC also rose significantly with chrysotile stimulation, but no change was observed when major histocompatibility complex (MHC) class II DP/DR positive cells were depleted. Therefore, our results support the possibility that silicate acts as a superantigen. | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7927506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7927506 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7927506 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:KawakamiYY | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:WatanabeYY | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:YamaguchiMM | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:UekiHH | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:UekiAA | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:HyodohFF | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:OhsawaGG | lld:pubmed |
| pubmed-article:7927506 | pubmed:author | pubmed-author:KinugawaKK | lld:pubmed |
| pubmed-article:7927506 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7927506 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:7927506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7927506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7927506 | pubmed:pagination | 332-5 | lld:pubmed |
| pubmed-article:7927506 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:meshHeading | pubmed-meshheading:7927506-... | lld:pubmed |
| pubmed-article:7927506 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7927506 | pubmed:articleTitle | Polyclonal human T-cell activation by silicate in vitro. | lld:pubmed |
| pubmed-article:7927506 | pubmed:affiliation | Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan. | lld:pubmed |
| pubmed-article:7927506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7927506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7927506 | lld:pubmed |
