| pubmed-article:7927494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1123019 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C0678894 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7927494 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:7927494 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7927494 | pubmed:dateCreated | 1994-10-21 | lld:pubmed |
| pubmed-article:7927494 | pubmed:abstractText | We have investigated several aspects of gamma delta T cells in sheep. gamma delta T cells of sheep express a unique transmembrane protein termed T19 but lack the expression of particular cell-surface molecules such as CD2, CD4 and CD8 which are typically associated with alpha beta T cells. The majority of gamma delta T cells isolated from animals of all ages examined lacked the expression of CD45RA. A faster rate of activation by gamma delta T cells compared to either CD4 or CD8 T cells was seen in the time-course of IL-2 receptor alpha chain (CD25) cell-surface expression. All gamma delta T cells expressed the CD25 protein within 8 hr of activation whereas the majority of CD4 or CD8 T cells did not express CD25 until 24 hr post-concanavalin A (Con A) stimulation. This difference in the rate of expression of activation molecules was not restricted to CD25, as a similar trend was seen with cell-surface expression of major histocompatibility complex (MHC) class II molecules. We have used the distinct phenotypic profile of ovine gamma delta T cells to purify these cells by positive selection via the T19 molecule to assess their in vitro proliferative response to various antigens. Routinely, cell populations comprising more than 93% gamma delta T cells with yields of approximately 55% were obtained. Purified gamma delta T cells were capable of responding to Mycobacterium tuberculosis antigen in a primary and secondary in vitro proliferation assay and to ovalbumin in a secondary response. Ovine gamma delta T cells showed little, if any, proliferative response to allogeneic stimulator cells. | lld:pubmed |
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| pubmed-article:7927494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7927494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7927494 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7927494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7927494 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7927494 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:7927494 | pubmed:author | pubmed-author:McConnellII | lld:pubmed |
| pubmed-article:7927494 | pubmed:author | pubmed-author:EvansC WCW | lld:pubmed |
| pubmed-article:7927494 | pubmed:author | pubmed-author:BujdosoRR | lld:pubmed |
| pubmed-article:7927494 | pubmed:author | pubmed-author:LundB TBT | lld:pubmed |
| pubmed-article:7927494 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7927494 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:7927494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7927494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7927494 | pubmed:pagination | 229-37 | lld:pubmed |
| pubmed-article:7927494 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7927494 | pubmed:meshHeading | pubmed-meshheading:7927494-... | lld:pubmed |
| pubmed-article:7927494 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7927494 | pubmed:articleTitle | Antigen recognition and activation of ovine gamma delta T cells. | lld:pubmed |
| pubmed-article:7927494 | pubmed:affiliation | Department of Veterinary Pathology, University of Edinburgh. | lld:pubmed |
| pubmed-article:7927494 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7927494 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
