Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1977-1-29
pubmed:abstractText
By the use of an in vitro insulin releasing system, new insights into the meechanisms underlying the insulin exocytotic process have been gained. It is proposed that insulin release is initiated by glucose interacting with a glucoreceptor on the plasma membrane. Some properties of this receptor are discussed. It is postulated that after initiation of secretion, continued insulin release is under the control of phosphorylated intermediates of glucose metabolism, i.e. glucose-6-phosphate and phosphoenol pyruvate, operating via a membrane-bound protein kinase. The initiation of insulin release by glucose, and the augmentation of this initiation by the above mentioned intermediates, is viewed as a modified cascade system. The cascade theory of insulin secretion is postulated as an alternative to the threshold distribution hypothesis of insulin secretion. The action of tolbutamide in relation to the two pool theory of insulin secretion is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-7948
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
787-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
An approach to a molecular understanding of exocytotic insulin release.
pubmed:publicationType
Journal Article, In Vitro