Linked Life Data

7924127

Source:http://linkedlifedata.com/resource/pubmed/id/7924127

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-10-28
pubmed:abstractText
A clinical trial of an analgesic agent compares pain relief scores (ordered categorical responses) over time among groups of patients, each subject to a painful procedure and given various doses of active agent (including zero, i.e., placebo) on demand. Patients may elect to remedicate with an active agent if their pain relief is insufficient, so the sample of patients at any given time is biased toward those with better relief. Standard analyses usually (1) fill in the missing data but make no correction for so doing and (2) treat the ordered categorical variable as continuous. Both of these create problems in interpretation and inference, but the former is more serious than the latter. An alternative analysis has been recently proposed that deals with these problems. This article presents that method for a nonstatistical audience and illustrates its use on some data from the analgesic bromfenac.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0009-9236
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
A new approach to the analysis of analgesic drug trials, illustrated with bromfenac data.
pubmed:affiliation
Department of Laboratory Medicine, School of Medicine, University of California San Francisco 94143-0626.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.