pubmed-article:7923883 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C0224522 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C1550315 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
pubmed-article:7923883 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:7923883 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:7923883 | pubmed:dateCreated | 1994-11-8 | lld:pubmed |
pubmed-article:7923883 | pubmed:abstractText | The present study was designed to establish (i) the effects of cytokines on soluble ICAM-1 (sICAM-1) production by human synovial cells (SC) and ICAM-1 expression on these cells, and (ii) the effects of sICAM-1 on lymphocyte-SC adhesion. sICAM-1 production was enhanced in parallel with ICAM-1 expression by IL-1 beta, TNF-alpha and IFN-gamma. IL-4 showed no effects on ICAM-1 expression. In contrast with the transient elevation of cell-associated ICAM-1 by IL-1 beta, which peaked 36 h after stimulation and declined thereafter, sICAM-1 continued to accumulate in culture supernatants even after 48 h. Purified sICAM-1 was obtained from a 48 h culture synovial cell supernatant by affinity chromatography using ICAM-1 monoclonal antibody. The purified sICAM-1 significantly inhibited adhesion of lymphocytes and monocytes to cytokine-stimulated synovial cells. These results suggest that sICAM-1 may modulate chronic synovitis by inhibiting ICAM-1-mediated cell-to-cell adhesion. | lld:pubmed |
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pubmed-article:7923883 | pubmed:language | eng | lld:pubmed |
pubmed-article:7923883 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7923883 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:7923883 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7923883 | pubmed:month | Oct | lld:pubmed |
pubmed-article:7923883 | pubmed:issn | 0009-9104 | lld:pubmed |
pubmed-article:7923883 | pubmed:author | pubmed-author:HashimotoMM | lld:pubmed |
pubmed-article:7923883 | pubmed:author | pubmed-author:EzakiII | lld:pubmed |
pubmed-article:7923883 | pubmed:author | pubmed-author:ShinguMM | lld:pubmed |
pubmed-article:7923883 | pubmed:author | pubmed-author:NobunagaMM | lld:pubmed |
pubmed-article:7923883 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7923883 | pubmed:volume | 98 | lld:pubmed |
pubmed-article:7923883 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7923883 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7923883 | pubmed:pagination | 46-51 | lld:pubmed |
pubmed-article:7923883 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
pubmed-article:7923883 | pubmed:meshHeading | pubmed-meshheading:7923883-... | lld:pubmed |
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pubmed-article:7923883 | pubmed:meshHeading | pubmed-meshheading:7923883-... | lld:pubmed |
pubmed-article:7923883 | pubmed:year | 1994 | lld:pubmed |
pubmed-article:7923883 | pubmed:articleTitle | Effect of cytokine-induced soluble ICAM-1 from human synovial cells on synovial cell-lymphocyte adhesion. | lld:pubmed |
pubmed-article:7923883 | pubmed:affiliation | Department of Clinical Immunology, Kyushu University, Beppu, Japan. | lld:pubmed |
pubmed-article:7923883 | pubmed:publicationType | Journal Article | lld:pubmed |
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