Linked Life Data

7923796

Source:http://linkedlifedata.com/resource/pubmed/id/7923796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-10-27
pubmed:abstractText
The influence of gonadotropin releasing hormone and Decapeptyl on steroidogenic activity was evaluated at concentrations of 0.1 ng/ml, 1 ng/ml and 10 ng/ml culture medium. In the granulosa cell cultures of 9 out of 18 patients addition of Decapeptyl or gonadotrophin releasing hormone to the culture media caused dose-dependent inhibition of progesterone and oestradiol secretion in vitro. The steroidogenic activity in vitro of the granulosa cells of 84 IVF cycles was correlated to the maximal serum E2 levels of the patients at induction of ovulation. The granulosa cells of patients who were stimulated including Decapeptyl produced on average higher E2 levels in vitro as compared to granulosa cells from hMG stimulation cycles. This may be regarded as an indirect clue to an inhibitory effect of Decapeptyl on oestradiol synthesis in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0390-6663
pubmed:author
pubmed:issnType
Print
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-9
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Influence of gonadotrophin releasing hormone (GnRH) and a GnRH-agonist on granulosa cell steroidogenesis.
pubmed:affiliation
Department of Obstetrics and Gynecology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
pubmed:publicationType
Journal Article