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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1994-10-31
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pubmed:abstractText |
Adenoviruses have been recently recognized as a highly efficient system for gene delivery to various tissues. The ability of replication-defective recombinant adenovirus to transfer the lacZ reporter gene encoding beta-galactosidase to nerve cells in various brain structures has been demonstrated. Here, on the continuation of these studies, we present evidence that the adenovirus can be transported in a retrograde manner to nerve cell bodies from axonal terminals. This method may be of great value for infecting selected subsets of specific neurons for either anatomo-functional studies or even therapeutic purposes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
13
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pubmed:volume |
648
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pubmed:geneSymbol |
lacZ
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7922521-Animals,
pubmed-meshheading:7922521-Avian Sarcoma Viruses,
pubmed-meshheading:7922521-Escherichia coli,
pubmed-meshheading:7922521-Genetic Vectors,
pubmed-meshheading:7922521-Male,
pubmed-meshheading:7922521-Neostriatum,
pubmed-meshheading:7922521-Neurons,
pubmed-meshheading:7922521-Rats,
pubmed-meshheading:7922521-Rats, Wistar,
pubmed-meshheading:7922521-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7922521-Tyrosine 3-Monooxygenase,
pubmed-meshheading:7922521-beta-Galactosidase
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pubmed:year |
1994
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pubmed:articleTitle |
Adenoviral vectors as functional retrograde neuronal tracers.
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pubmed:affiliation |
Institut Alfred Fessard, Centre National de la Recherche Scientifique [CNRS], Gif sur Yvette, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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