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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-11-1
|
| pubmed:abstractText |
Evaluation of a number of cytotoxic antitumor sesquiterpene lactones and their derivatives has led to the discovery of bis(helenalinyl)glutarate (4) and bis(isoalantodiol-B)glutarate (10) as potent inhibitors of human-derived topoisomerase II. Unlike etoposide, which inhibits by preventing the DNA rejoining process, compounds 4 and 10 inhibit topoisomerase II without causing DNA breakage. The structure-activity relationships of 4, 10, and related compounds are discussed.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
137-45
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7922123-Cell Line,
pubmed-meshheading:7922123-DNA,
pubmed-meshheading:7922123-Drug Evaluation, Preclinical,
pubmed-meshheading:7922123-Humans,
pubmed-meshheading:7922123-Lactones,
pubmed-meshheading:7922123-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7922123-Models, Molecular,
pubmed-meshheading:7922123-Molecular Conformation,
pubmed-meshheading:7922123-Sesquiterpenes,
pubmed-meshheading:7922123-Structure-Activity Relationship,
pubmed-meshheading:7922123-Topoisomerase II Inhibitors
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Antitumor agents--CLI. Bis(helenalinyl)glutarate and bis(isoalantodiol-B)glutarate, potent inhibitors of human DNA topoisomerase II.
|
| pubmed:affiliation |
Natural Products Laboratory, Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
|
| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|