Linked Life Data

7921748

Source:http://linkedlifedata.com/resource/pubmed/id/7921748

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1994-11-18
pubmed:abstractText
Mechanical load is an important regulator of chondrocyte metabolic activity. Changes in amplitude or frequency of the load can have a significant effect on the production of matrix macromolecules and of agents leading to cartilage breakdown. The composition of cartilage reflects the net response of the chondrocytes to the prevailing loading pattern, with cartilage proteoglycan content highest in heavily loaded regions and removal of load leading to cartilage thinning and proteoglycan loss. The mechanism of mechanotransduction is poorly understood; the chondrocytes appear to react to cartilage deformation and to the changes in hydrostatic pressure, extracellular ionic composition and streaming potentials induced by the load.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0263-7103
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
901-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The chondrocyte: a cell under pressure.
pubmed:affiliation
Physiology Laboratory, Oxford University.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't