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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-11-17
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pubmed:abstractText |
p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this complex on chromosome 1 was either deleted or translocated in each of 18 neuroblastoma cell lines with cytogenetically apparent 1p alterations. A protein encoded by this locus, PITSLRE gamma 1, was absent in three of the lines and a smaller, apparently truncated, PITSLRE polypeptide was found in another line. These findings identify a novel gene complex on chromosome 1 that encodes a protein kinase subfamily. We suggest that the PITSLRE locus may harbour one or more tumour suppressor genes affected by chromosome 1p36 modifications in neuroblastoma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:geneSymbol |
N-myc,
PITSLRE,
PITSLRE A,
PITSLRE B,
PITSLRE C
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
370-5
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pubmed:dateRevised |
2011-10-10
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pubmed:meshHeading |
pubmed-meshheading:7920654-Alleles,
pubmed-meshheading:7920654-Child,
pubmed-meshheading:7920654-Child, Preschool,
pubmed-meshheading:7920654-Chromosomes, Human, Pair 1,
pubmed-meshheading:7920654-Cyclin-Dependent Kinases,
pubmed-meshheading:7920654-Genes,
pubmed-meshheading:7920654-Genes, Tumor Suppressor,
pubmed-meshheading:7920654-Humans,
pubmed-meshheading:7920654-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7920654-Infant,
pubmed-meshheading:7920654-Monosomy,
pubmed-meshheading:7920654-Multigene Family,
pubmed-meshheading:7920654-Neuroblastoma,
pubmed-meshheading:7920654-Protein Kinases,
pubmed-meshheading:7920654-Protein-Serine-Threonine Kinases,
pubmed-meshheading:7920654-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7920654-Sequence Deletion,
pubmed-meshheading:7920654-Translocation, Genetic,
pubmed-meshheading:7920654-Tumor Cells, Cultured
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pubmed:year |
1994
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pubmed:articleTitle |
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.
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pubmed:affiliation |
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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