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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1994-11-9
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pubmed:abstractText |
HLA-DP typing is not routinely performed before allogeneic BMT. This highly polymorphic class II locus is implicated in immune response and DP molecules may act as transplantation antigens. HLA-DP incompatibilities contribute to MCL. In BMT performed between siblings, HLA-DP mismatches are rare and the role of such incompatibility in GVHD is probably lower than minor histocompatibility antigen disparity. In unrelated BMT, the rate of HLA-DP mismatches is high and DP incompatibility cannot be used as an exclusion criterion in the selection of unrelated donors. Even if in vitro studies show that the HLA-DP antigen may be the target for GVHD, analysis of large numbers of unrelated BMT shows that DP incompatibility is not a risk factor for acute GVHD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0268-3369
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
675-81
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7920290-Amino Acid Sequence,
pubmed-meshheading:7920290-Bone Marrow Transplantation,
pubmed-meshheading:7920290-Graft vs Host Disease,
pubmed-meshheading:7920290-HLA-DP Antigens,
pubmed-meshheading:7920290-Histocompatibility Testing,
pubmed-meshheading:7920290-Humans,
pubmed-meshheading:7920290-Molecular Sequence Data,
pubmed-meshheading:7920290-Transplantation, Homologous
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pubmed:year |
1994
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pubmed:articleTitle |
HLA-DP and allogeneic bone marrow transplantation.
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pubmed:affiliation |
Department of Haematology CHU Hôtel-Dieu, Nantes, France.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Review
|