| pubmed-article:7918632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0023440 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0525013 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0005221 | lld:lifeskim |
| pubmed-article:7918632 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7918632 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7918632 | pubmed:dateCreated | 1994-11-15 | lld:pubmed |
| pubmed-article:7918632 | pubmed:abstractText | In this paper we describe a complete deletional analysis of hypersensitive site three (HS3) of the human beta-globin Locus Control Region (LCR). The previously defined core fragment consists of 6 footprinted regions, with multiple binding sites for the erythroid-specific factor GATA-1 and G-rich motifs that can interact with ubiquitous factors such as Sp1 and TEF-2. We show in this paper that the 5' half of this fragment is the most important for activity in murine erythroleukemia (MEL) cells. A fragment containing footprints 1-4 can stimulate transcription of a linked human beta-globin gene to levels of about 40% of that obtained with footprints 1-6. Constructs containing either footprints 1-3 or 3-6 cannot be distinguished from the beta-globin gene alone. We further show that binding sites for the erythroid-specific factor NF-E2 can co-operatively interact with parts of the HS3 core fragment, and that HS3 requires elements upstream from -103 in the human beta-globin promoter for full activity. The importance of these results is discussed in the context of the regulation of the genes in the human beta-globin cluster. | lld:pubmed |
| pubmed-article:7918632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7918632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7918632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7918632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7918632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7918632 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7918632 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:7918632 | pubmed:author | pubmed-author:HurstJJ | lld:pubmed |
| pubmed-article:7918632 | pubmed:author | pubmed-author:AntoniouMM | lld:pubmed |
| pubmed-article:7918632 | pubmed:author | pubmed-author:GrosveldFF | lld:pubmed |
| pubmed-article:7918632 | pubmed:author | pubmed-author:PhilipsenSS | lld:pubmed |
| pubmed-article:7918632 | pubmed:author | pubmed-author:PruzinaSS | lld:pubmed |
| pubmed-article:7918632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7918632 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:7918632 | pubmed:volume | 1219 | lld:pubmed |
| pubmed-article:7918632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7918632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7918632 | pubmed:pagination | 351-60 | lld:pubmed |
| pubmed-article:7918632 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7918632 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7918632 | pubmed:articleTitle | Transcriptional activation by hypersensitive site three of the human beta-globin locus control region in murine erythroleukemia cells. | lld:pubmed |
| pubmed-article:7918632 | pubmed:affiliation | National Institute for Medical Research, London, UK. | lld:pubmed |
| pubmed-article:7918632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7918632 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7918632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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