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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1994-11-10
|
| pubmed:abstractText |
1. We have clarified the influence of 18 covariates on cadaveric renal graft survival rates and their interactions with the center effect. With the United States government releasing center-specific survival rates, alternative and broader definitions of the center effect are warranted. We have enhanced the grading system for centers by simultaneously evaluating 2 posttransplantation time-points-3-months and 2 years. 2. These results demonstrate that the proportion of cases in all factor categories were relatively independent of transplant center (ie, modest V values, generally much less than 0.1). One explanation for factors showing slight association (V approximately 0.1) with patient-mix-adjusted center effects is the presence of hidden factors (eg, social, economic status) associated with both factor and center success. 3. The short- and long-term effects of many factors were constant across center grades. For example, the initial risk of cadaveric graft failure was increased for a sensitized (> 10% PRA), young (< 20 years), or old (65 years) patient regrafted with any DR-mismatched kidney prior to 1991, regardless of center grade. Similarly, the prognosis for a young (< 7) or old (> 65), African-American, or IDDM recipient of a cadaveric older-donor kidney would be poor, regardless of where the patient was transplanted. 4. A few notable factor effects materialized consistently with a particular epoch of centers including early effects due to recipient race and working status only at centers with inherently poor early graft function, and long-term effects due to donor sex exclusively at centers with poor long-term outcomes.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0890-9016
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
445-68
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| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7918180-Adolescent,
pubmed-meshheading:7918180-Adult,
pubmed-meshheading:7918180-Aged,
pubmed-meshheading:7918180-Child,
pubmed-meshheading:7918180-Child, Preschool,
pubmed-meshheading:7918180-Female,
pubmed-meshheading:7918180-Graft Survival,
pubmed-meshheading:7918180-Humans,
pubmed-meshheading:7918180-Infant,
pubmed-meshheading:7918180-Infant, Newborn,
pubmed-meshheading:7918180-Kidney Transplantation,
pubmed-meshheading:7918180-Male,
pubmed-meshheading:7918180-Middle Aged,
pubmed-meshheading:7918180-Multivariate Analysis,
pubmed-meshheading:7918180-Registries,
pubmed-meshheading:7918180-Risk Factors,
pubmed-meshheading:7918180-Survival Rate,
pubmed-meshheading:7918180-Tissue and Organ Procurement,
pubmed-meshheading:7918180-Transplantation, Homologous
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Center-dependent transplantation factors: an analysis of renal allografts reported to the United Network for Organ Sharing Registry.
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| pubmed:publicationType |
Journal Article
|