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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1994-10-26
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pubmed:abstractText |
In vitro megakaryocyte colony formation was studied in 25 patients with chronic idiopathic thrombocytopenic purpura (ITP), and compared to 16 controls. A significantly lower number of megakaryocyte progenitors (CFU-MK) was observed in patients (10.8 +/- 12.0 CFU-MK per 10(5) bone-marrow non-adherent mononuclear cells (NAMC), compared to controls (22.5 +/- 15.4 CFU-MK); P < 0.002. Only six patients had a normal number of CFU-MK. The number of CFU-MK was not correlated to initial platelet count (P = 0.35). These findings indicate that in vitro CFU-MK could be of interest in the diagnosis of chronic ITP, and also could be predictive for chronicity in patients with acute ITP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1048
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
803-4
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7918047-Adult,
pubmed-meshheading:7918047-Aged,
pubmed-meshheading:7918047-Aged, 80 and over,
pubmed-meshheading:7918047-Chronic Disease,
pubmed-meshheading:7918047-Colony-Forming Units Assay,
pubmed-meshheading:7918047-Female,
pubmed-meshheading:7918047-Granulocytes,
pubmed-meshheading:7918047-Humans,
pubmed-meshheading:7918047-Male,
pubmed-meshheading:7918047-Megakaryocytes,
pubmed-meshheading:7918047-Middle Aged,
pubmed-meshheading:7918047-Platelet Count,
pubmed-meshheading:7918047-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:7918047-Stem Cells
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pubmed:year |
1993
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pubmed:articleTitle |
Decreased in vitro megakaryocyte colony formation in chronic idiopathic thrombocytopenic purpura.
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pubmed:affiliation |
Department of Haematology, University of Brest, School of Medicine, France.
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pubmed:publicationType |
Journal Article
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