Linked Life Data

7917237

Source:http://linkedlifedata.com/resource/pubmed/id/7917237

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-11-18
pubmed:abstractText
The emergence of a wide variety of biological expression systems for the large-scale production of therapeutic proteins has shifted the focus from vectors to host organisms. Although expression systems now span bacteria, fungi, plants, insects, and mammalian cells, the vast majority of recombinant-derived biopharmaceuticals at the present time have been produced in Escherichia coli and in mammalian cells. This promises to change as the economic benefits of the newer systems permit the development of a new generation of proteins heretofore considered unfeasible for commercial development. Despite the impressive results which have been observed for many of the newer systems, there are many commercial considerations which suggest that E. coli and CHO cell expression systems may continue to dominate the manufacture of biopharmaceuticals for a long time to come.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1045-1056
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-94
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The molecular biology of production cell lines.
pubmed:affiliation
Sierra BioResource, Inc., Gilroy, CA 95020.
pubmed:publicationType
Journal Article, Review