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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-10-20
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10583,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10584,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10585,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10586,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10587,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10588,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10589,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10590,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10591,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10592,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10593,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10594,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10595,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10596,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10597,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10598,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10599,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10600,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10601,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10602,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10603,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10604,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10605,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10606,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10607,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10608,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10609,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10610,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10611,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U10612
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pubmed:abstractText |
The primary targets for infection of HIV-1 are CD4+ T cells and monocyte/macrophage cells. We investigated the genotype heterogeneity of HIV-1 in distinct blood compartments, CD4+ T cells, monocytes, and plasma. Nucleotide sequences of proviral DNA from CD4+ T cells, monocyte cells, and cell-free virion RNA from plasma were determined in three HIV-1 infected individuals. We found that the heterogeneity in proviral DNA from CD4+ T cells was much higher than that found in monocyte cells or in virion RNA from plasma. These data showed that different swarms of HIV-1 exist in individually infected cells and plasma. Furthermore, predicted V3 amino acid sequences in the infected monocytes were very similar to the reported sequence of prototypic macrophage-tropic HIV-1 isolates. Our results show that macrophage-tropic virus is quite homogeneous in monocytes/macrophages and has a common V3 structure in contrast to T-cell-tropic virus in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
204
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
170-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7916512-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7916512-Amino Acid Sequence,
pubmed-meshheading:7916512-Antigens, CD4,
pubmed-meshheading:7916512-Base Sequence,
pubmed-meshheading:7916512-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7916512-DNA, Viral,
pubmed-meshheading:7916512-Genes, env,
pubmed-meshheading:7916512-Genetic Variation,
pubmed-meshheading:7916512-HIV Envelope Protein gp120,
pubmed-meshheading:7916512-HIV Infections,
pubmed-meshheading:7916512-HIV-1,
pubmed-meshheading:7916512-Humans,
pubmed-meshheading:7916512-Macrophages,
pubmed-meshheading:7916512-Male,
pubmed-meshheading:7916512-Molecular Sequence Data,
pubmed-meshheading:7916512-Monocytes,
pubmed-meshheading:7916512-Peptide Fragments,
pubmed-meshheading:7916512-Protein Structure, Secondary,
pubmed-meshheading:7916512-Proviruses,
pubmed-meshheading:7916512-RNA, Viral,
pubmed-meshheading:7916512-Sequence Alignment,
pubmed-meshheading:7916512-Sequence Analysis, DNA
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pubmed:year |
1994
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pubmed:articleTitle |
Cell type-specific heterogeneity of the HIV-1 V3 loop in infected individuals: selection of virus in macrophages and plasma.
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pubmed:affiliation |
Department of Microbiology, Tokyo Medical and Dental University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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