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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5180
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pubmed:dateCreated |
1994-10-19
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pubmed:abstractText |
Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor activation. Previous results suggest that the site for both the induction and expression of this form of LTP is presynaptic. Experimental elevation of cyclic adenosine 3',5'-monophosphate (cAMP) both mimics and interferes with tetanus-induced mossy fiber LTP, and blockers of the cAMP cascade block mossy fiber LTP. It is proposed that calcium entry into the presynaptic terminal may activate Ca(2+)-calmodulin-sensitive adenylyl cyclase I which, through protein kinase A, causes a persistent enhancement of evoked glutamate release.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carbazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/KT 5720,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-(4-bromocinnamylamino)ethyl)-5-...,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
265
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1878-82
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7916482-Animals,
pubmed-meshheading:7916482-Calcium,
pubmed-meshheading:7916482-Carbazoles,
pubmed-meshheading:7916482-Cyclic AMP,
pubmed-meshheading:7916482-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:7916482-Forskolin,
pubmed-meshheading:7916482-Glutamates,
pubmed-meshheading:7916482-Glutamic Acid,
pubmed-meshheading:7916482-Guinea Pigs,
pubmed-meshheading:7916482-Hippocampus,
pubmed-meshheading:7916482-Indoles,
pubmed-meshheading:7916482-Isoquinolines,
pubmed-meshheading:7916482-Long-Term Potentiation,
pubmed-meshheading:7916482-Models, Biological,
pubmed-meshheading:7916482-Nerve Fibers,
pubmed-meshheading:7916482-Presynaptic Terminals,
pubmed-meshheading:7916482-Pyramidal Cells,
pubmed-meshheading:7916482-Pyrroles,
pubmed-meshheading:7916482-Sulfonamides,
pubmed-meshheading:7916482-Synaptic Transmission
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pubmed:year |
1994
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pubmed:articleTitle |
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
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pubmed:affiliation |
Neuroscience Graduate Program, University of California, San Francisco 94143-0450.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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