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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0017258,
umls-concept:C0017337,
umls-concept:C0086418,
umls-concept:C0162801,
umls-concept:C0282552,
umls-concept:C0379885,
umls-concept:C1332692,
umls-concept:C1516050,
umls-concept:C1520763,
umls-concept:C1704902
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pubmed:issue |
2
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pubmed:dateCreated |
1994-10-20
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pubmed:databankReference |
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pubmed:abstractText |
Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was completed. In addition to a dense region with direct and inverted repeats and palindromic sequences, a double microsatellite (CA)n-(GA)n' was found at the 5'-end of the MCP-3 gene, and an RFLP was detected. The gene was regionally mapped by fluorescence in situ hybridization to human chromosome 17, subbands q11.2-q12. This site contains the MCP-subset of C-C chemokines and can be distinguished from the syntenic MIP-1 alpha locus. SCYA7 was assigned as the locus symbol of the MCP-3 gene. Double-labeling experiments confirmed the regional assignment of the MCP-3 gene close to the ERBB2 locus on human chromosome 17.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCL7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL7,
http://linkedlifedata.com/resource/pubmed/chemical/Chemotactic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Satellite,
http://linkedlifedata.com/resource/pubmed/chemical/Deoxyribonuclease BamHI,
http://linkedlifedata.com/resource/pubmed/chemical/Monocyte Chemoattractant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7916328-Amino Acid Sequence,
pubmed-meshheading:7916328-Animals,
pubmed-meshheading:7916328-Base Sequence,
pubmed-meshheading:7916328-Blotting, Southern,
pubmed-meshheading:7916328-Chemokine CCL7,
pubmed-meshheading:7916328-Chemotactic Factors,
pubmed-meshheading:7916328-Chromosome Mapping,
pubmed-meshheading:7916328-Chromosomes, Human, Pair 17,
pubmed-meshheading:7916328-Cloning, Molecular,
pubmed-meshheading:7916328-Consensus Sequence,
pubmed-meshheading:7916328-Cytokines,
pubmed-meshheading:7916328-DNA, Satellite,
pubmed-meshheading:7916328-Deoxyribonuclease BamHI,
pubmed-meshheading:7916328-Female,
pubmed-meshheading:7916328-Hominidae,
pubmed-meshheading:7916328-Humans,
pubmed-meshheading:7916328-In Situ Hybridization, Fluorescence,
pubmed-meshheading:7916328-Introns,
pubmed-meshheading:7916328-Male,
pubmed-meshheading:7916328-Molecular Sequence Data,
pubmed-meshheading:7916328-Monocyte Chemoattractant Proteins,
pubmed-meshheading:7916328-Multigene Family,
pubmed-meshheading:7916328-Pedigree,
pubmed-meshheading:7916328-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7916328-Proto-Oncogene Proteins,
pubmed-meshheading:7916328-Receptor, Epidermal Growth Factor,
pubmed-meshheading:7916328-Receptor, erbB-2,
pubmed-meshheading:7916328-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:7916328-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7916328-Restriction Mapping
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pubmed:year |
1994
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pubmed:articleTitle |
The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2-q12.
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pubmed:affiliation |
Rega Institute, University of Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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