Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-10-20
|
| pubmed:abstractText |
This study showed that non-MHC genes common to (DBA/2 H-2d) and (DBA/1 H-2q) gave rise to suppressor T (Ts) cells in the hybrid F1 mice between C57BL/6 (B6) strain in the anti-FBL-3 tumor responses. FBL-3, a Friend virus-induced tumor cell line of B6 mouse origin, is highly immunogenic as shown by findings that syngeneic and hybrid F1 mice with several other inbred strains rejected up to 3 x 10(7) tumors cell inoculated s.c. and generated potent CTL responses after mixed lymphocyte tumor cell culture. In contrast to these mice, (B6 x DBA/2) and (B6 x DBA/1)F1 mice did not reject the tumor as the tumor doses increased. Progressive tumor growth in these F1 mice was blocked by an i.p. injection of cyclophosphamide (250 mg/kg) on day 10, but not on day 5, after tumor cell inoculation. Anti-CD4 (GK1.5) mAb exerted similar therapeutic effects against tumor when given twice, between day 0 and 10, whereas the additional injection of anti-CD8 mAb enhanced the tumor growth in mice that otherwise rejected the tumor. Thus, in the response of (B6 x DBA/2)F1 mice to FBL-3 tumor cells, CD4+ Ts seemed to down-regulate the immunologically mediated regression of the tumor produced by CD8+ CTL. This was evidenced by limiting dilution culture analyses, which showed that the frequency of an FBL-3-specific CTL precursor in the (B6 x DBA/2)F1 mice that rejected the tumor with anti-CD4 mAb was approximately 7- to 9-fold higher than that in mice in which the tumor regressed spontaneously.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0953-8178
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
839-46
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7916205-Animals,
pubmed-meshheading:7916205-Antibodies, Monoclonal,
pubmed-meshheading:7916205-Antigens, CD8,
pubmed-meshheading:7916205-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7916205-Cyclophosphamide,
pubmed-meshheading:7916205-Cytotoxicity, Immunologic,
pubmed-meshheading:7916205-Female,
pubmed-meshheading:7916205-Hybridization, Genetic,
pubmed-meshheading:7916205-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:7916205-Male,
pubmed-meshheading:7916205-Mice,
pubmed-meshheading:7916205-Mice, Inbred Strains,
pubmed-meshheading:7916205-Neoplasm Transplantation,
pubmed-meshheading:7916205-Neoplasms, Experimental,
pubmed-meshheading:7916205-T-Lymphocyte Subsets,
pubmed-meshheading:7916205-Tumor Cells, Cultured
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Effects of non-MHC background genes on the induction of CD4+ T cells that prevent rejection of a highly immunogenic tumor, FBL-3.
|
| pubmed:affiliation |
Department of Immunology and Cell Biology, Faculty of Medicine, Kyoto University, Japan.
|
| pubmed:publicationType |
Journal Article
|