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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1994-10-13
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pubmed:abstractText |
Selective alpha- and beta-adrenergic agonists and antagonists were used to determine the action of catecholamines on fatty acid biosynthesis in freshly isolated human mononuclear leukocytes. Incubation of cells for 22 h in a lipid-free medium resulted in a 4-fold increase in the incorporation of [14C]acetate into fatty acids. Addition of (-)-epinephrine in increasing concentrations to the incubation medium inhibited the rate of fatty acid synthesis by 42% at a concentration of 0.1 M. Similar effects were observed using (-)-norepinephrine and the beta-agonist isoproterenol. The catecholamine action was diminished by the unselective beta-blocker propranolol and mimicked by dibutyryl cyclic AMP. Since human mononuclear leukocytes possess beta 2-, but not beta 1-adrenoceptors (Brodde, Engel and Hoyer 1981), catecholamines may act via beta-adrenergic receptors of the beta 2-subtype. In addition, it appears that stimulation of alpha-adrenergic receptors inhibits fatty acid synthesis, too. In the presence of a beta-blockade by 1 microM propranolol, the alpha 2-agonist alpha-methylnorepinephrine, but not the alpha 1-agonist phenylephrine inhibited fatty acid synthesis rate. Accordingly, the epinephrine effect was attenuated by the alpha 2-antagonist yohimbine, but not by the alpha 1-antagonist prazosin. The results provide evidence that catecholamines may inhibit the synthesis rate of fatty acids by stimulation of both, beta 2- and alpha 2-adrenergic receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-1 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0018-5043
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-72
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7916000-Adrenergic alpha-1 Receptor Antagonists,
pubmed-meshheading:7916000-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:7916000-Adrenergic alpha-Agonists,
pubmed-meshheading:7916000-Adrenergic alpha-Antagonists,
pubmed-meshheading:7916000-Adrenergic beta-1 Receptor Antagonists,
pubmed-meshheading:7916000-Adrenergic beta-2 Receptor Antagonists,
pubmed-meshheading:7916000-Adrenergic beta-Agonists,
pubmed-meshheading:7916000-Adrenergic beta-Antagonists,
pubmed-meshheading:7916000-Fatty Acids,
pubmed-meshheading:7916000-Humans,
pubmed-meshheading:7916000-Leukocytes, Mononuclear,
pubmed-meshheading:7916000-Receptors, Adrenergic, alpha,
pubmed-meshheading:7916000-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:7916000-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:7916000-Receptors, Adrenergic, beta,
pubmed-meshheading:7916000-Receptors, Adrenergic, beta-1,
pubmed-meshheading:7916000-Receptors, Adrenergic, beta-2
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pubmed:year |
1994
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pubmed:articleTitle |
Inhibition of fatty acid synthesis by stimulation of alpha- and beta-adrenergic receptors in human mononuclear leukocytes.
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pubmed:affiliation |
Klinik II and Poliklinik für Innere Medizin, Universität zu Köln, Cologne, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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