Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-9-1
|
| pubmed:abstractText |
Kawasaki disease (KD) is the leading cause of acquired heart disease in children in the United States. The etiology is unknown. Data regarding the presence of T cell activation and its potential role in the pathogenesis of the disease have been conflicting. Expansion of T cells bearing V beta 2 and V beta 8 has recently been reported in the acute phase of KD, which suggests that a superantigen may mediate the disease process. To further assess the potential role of T cells in KD, T cell phenotypes were evaluated by using flow cytometry in a large series of patients, acutely and during convalescence. Included in this analysis were assessments of changes in the percentage of T cells bearing TCR V beta 2, V beta 5.1, V beta 6.7, V beta 8, V beta 12.1, and V beta 19 over time; the percentage of each V beta family bearing the activation markers HLA-DR and IL-2R; and the percentage of each V beta family bearing the memory marker, CD45RO. No expansion of any V beta family was present acutely, nor were increases in HLA-DR and IL-2R observed. However, a significant increase was observed during convalescence in the percentage of cells bearing CD45RO in the CD8+, but not the CD4+, population. CD45RO expression was also increased on V beta 2, V beta 8, and V beta 19 CD8+ T cells in a subset of patients. These data suggest that one or more conventional Ags drive the T cell immune response in KD, and argue against a role for superantigens in the disease process.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
153
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1881-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7913945-Acute Disease,
pubmed-meshheading:7913945-Adolescent,
pubmed-meshheading:7913945-Antigens, CD45,
pubmed-meshheading:7913945-Antigens, CD8,
pubmed-meshheading:7913945-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7913945-Child,
pubmed-meshheading:7913945-Child, Preschool,
pubmed-meshheading:7913945-Female,
pubmed-meshheading:7913945-Follow-Up Studies,
pubmed-meshheading:7913945-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:7913945-Humans,
pubmed-meshheading:7913945-Infant,
pubmed-meshheading:7913945-Lymphocyte Activation,
pubmed-meshheading:7913945-Male,
pubmed-meshheading:7913945-Mucocutaneous Lymph Node Syndrome,
pubmed-meshheading:7913945-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7913945-T-Lymphocyte Subsets,
pubmed-meshheading:7913945-Time Factors
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
TCR V beta family repertoire and T cell activation markers in Kawasaki disease.
|
| pubmed:affiliation |
Division of Cardiology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|