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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-8-25
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pubmed:abstractText |
We attempted to clarify whether or not under inhibition of central dopa decarboxylase non-effective i.p. doses of L-dopa potentiate D2 receptor-mediated locomotor activities without conversion to dopamine in normal and i.v.t. 6-hydroxydopamine-treated rats. In normal rats, only the highest dose of quinpirole, a selective D2 agonist, at ranges used (0.01-1 mg/kg, s.c.) slightly increased the total counts of locomotor activities for 140 min after injection. A simultaneously injected non-effective dose of L-DOPA (30 mg/kg) potentiated locomotor activities by quinpirole (0.1 and 1 mg/kg). L-dopa potentiated quinpirole (1 mg/kg)-induced locomotor activities 90 to 140 min after the injection with marked increase in basal release of L-DOPA without increase in dopamine release simultaneously monitored during striatal microdialysis, compared to quinpirole alone. D-dopa (30 mg/kg) produced no potentiation. In 6-hydroxydopamine-treated rats, a non-effective dose of L-dopa (10 mg/kg) also potentiated quinpirole (0.3 mg/kg)-induced locomotor activities. L-dopa acting on a recognition site for itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-hydroxybenzylhydrazine,
http://linkedlifedata.com/resource/pubmed/chemical/Aromatic-L-Amino-Acid Decarboxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Desipramine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopa Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrazines,
http://linkedlifedata.com/resource/pubmed/chemical/Levodopa,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
170
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
22-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7913743-Animals,
pubmed-meshheading:7913743-Aromatic-L-Amino-Acid Decarboxylases,
pubmed-meshheading:7913743-Desipramine,
pubmed-meshheading:7913743-Dopa Decarboxylase,
pubmed-meshheading:7913743-Dopamine Agents,
pubmed-meshheading:7913743-Ergolines,
pubmed-meshheading:7913743-Hydrazines,
pubmed-meshheading:7913743-Injections, Intraventricular,
pubmed-meshheading:7913743-Levodopa,
pubmed-meshheading:7913743-Male,
pubmed-meshheading:7913743-Microdialysis,
pubmed-meshheading:7913743-Motor Activity,
pubmed-meshheading:7913743-Nerve Fibers,
pubmed-meshheading:7913743-Oxidopamine,
pubmed-meshheading:7913743-Quinpirole,
pubmed-meshheading:7913743-Rats,
pubmed-meshheading:7913743-Rats, Sprague-Dawley,
pubmed-meshheading:7913743-Receptors, Dopamine D2,
pubmed-meshheading:7913743-Stereoisomerism
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pubmed:year |
1994
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pubmed:articleTitle |
Non-effective dose of exogenously applied L-dopa itself stereoselectively potentiates postsynaptic D2 receptor-mediated locomotor activities of conscious rats.
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pubmed:affiliation |
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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