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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-8-18
|
| pubmed:abstractText |
1. Although the high-frequency fluctuations in R-R interval (respiratory sinus arrhythmia) observed in heart transplant recipients are not a reliable marker of reinnervation because of a previously shown direct mechanical effect of breathing, the presence of a non-respiration-related low-frequency oscillation reflects rhythms generated outside the heart, and thus could be neurally mediated. 2. To evaluate the presence of reinnervation, the spontaneous variability in R-R interval was investigated, supine and after passive tilting, in 23 heart transplant recipients (age 43 years, range 23-64 years) and in 25 normotensive control subjects by autoregressive spectral analysis of low- and high-frequency spontaneous fluctuations in R-R interval and respiration. The response of R-R interval to amyl nitrite inhalation was also evaluated in five heart transplant recipients and eight control subjects. 3. Detectable low-frequency oscillations, unrelated to respiration, were present in 13/23 heart transplant recipients, particularly in those who were transplanted at least 20 months earlier (11/14). The natural logarithm of the power of low-frequency fluctuations was markedly lower than in control subjects (0.75 +/- 0.21 versus 5.62 +/- 0.20 ms2, P < 0.001). The low-frequency but not the high-frequency fluctuations correlated with time since transplantation (r = 0.44, P < 0.05). The subjects with low-frequency fluctuations showed a sudden decrease in R-R interval with amyl nitrite linearly related to the decrease in mean blood pressure (r > or = 0.94). The slopes obtained in these heart transplant recipients were comparable (although of lower values) with those obtained in control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0143-5221
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
86
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
537-45
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7913430-Adult,
pubmed-meshheading:7913430-Amyl Nitrite,
pubmed-meshheading:7913430-Autonomic Nervous System,
pubmed-meshheading:7913430-Heart,
pubmed-meshheading:7913430-Heart Rate,
pubmed-meshheading:7913430-Heart Transplantation,
pubmed-meshheading:7913430-Humans,
pubmed-meshheading:7913430-Middle Aged,
pubmed-meshheading:7913430-Postoperative Period,
pubmed-meshheading:7913430-Posture,
pubmed-meshheading:7913430-Respiration,
pubmed-meshheading:7913430-Stimulation, Chemical
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Non-respiratory components of heart rate variability in heart transplant recipients: evidence of autonomic reinnervation?
|
| pubmed:affiliation |
Dipartimento di Medicina Interna, Sezione Clinica Medica I, Pavia, Italy.
|
| pubmed:publicationType |
Journal Article
|