Linked Life Data

7912839

Source:http://linkedlifedata.com/resource/pubmed/id/7912839

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-8-4
pubmed:abstractText
Previous results have shown that chronic administration of the antidepressant trimipramine prevents the formation of long-term potentiation in the rat hippocampus. In the present study, we compared the effects of chronic administration of trimipramine on the binding properties of hippocampal glutamate receptors and on the modulation of the DL-alpha-amino-3-hydroxy-5- methyl-isoxazolpropionic acid (AMPA) receptors by phospholipase A2 (PLA2). Whereas the binding characteristics of various agonist and antagonist ligands to the N-methyl-D-aspartate and the AMPA receptors were not modified by trimipramine treatment, there was a significant reduction in the increase in 3H-AMPA binding elicited by PLA2 treatment. Since activation of PLA2 has been reported to play a critical role in the formation of long-term potentiation, possibly mediated through a modification of the AMPA receptors, the results strengthen the hypothesis that PLA2-induced modification of 3H-AMPA binding is an important component of synaptic plasticity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0165-1781
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-14
pubmed:dateRevised
2008-4-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Modulation of the AMPA receptor by phospholipase A2: effect of the antidepressant trimipramine.
pubmed:affiliation
Neurological Sciences Program, Université de Montréal, Québec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't