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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1 Pt 1
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pubmed:dateCreated |
1994-7-29
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pubmed:abstractText |
Hepatitis B virus with a G-to-A point mutation at nucleotide 83 in the precore region (mutant hepatitis B virus 83), which cannot produce HBeAg, is commonly found in HBe antibody-positive hepatitis B virus carriers. We analyzed the consecutive changes in the prevalence of mutant hepatitis B virus 83 during the course of chronic hepatitis B virus infection. Forty-five patients with chronic hepatitis B who were followed up for more than 2 yr in our hospital were studied by polymerase chain reaction in combination with a restriction fragment length polymorphism assay. Mutant hepatitis B virus 83 was found in 14 of 18 (78%) HBe antibody-positive patients and in 8 of 27 (30%) HBeAg-positive patients at baseline. Eighteen of the 22 patients who had mutant hepatitis B virus 83 (82%) showed mixed viral populations of wild-type hepatitis B virus and mutant hepatitis B virus 83, whereas 4 (18%) had only mutant hepatitis B virus 83 and were positive for HBe antibody. During a 2 yr follow-up period, mutant hepatitis B virus 83 was newly detected in 9 of 23 (39%) patients who had wild-type hepatitis B virus alone at baseline. The proportion of mutant hepatitis B virus 83 to whole hepatitis B virus in the serum of 18 patients with mixed viral populations at baseline fluctuated during follow-up. In contrast, wild-type hepatitis B virus was never detected throughout the study in all four patients who had only mutant hepatitis B virus 83 at baseline.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0270-9139
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8-14
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7912688-Adult,
pubmed-meshheading:7912688-Base Sequence,
pubmed-meshheading:7912688-Chronic Disease,
pubmed-meshheading:7912688-Female,
pubmed-meshheading:7912688-Follow-Up Studies,
pubmed-meshheading:7912688-Hepatitis B,
pubmed-meshheading:7912688-Hepatitis B Antibodies,
pubmed-meshheading:7912688-Hepatitis B e Antigens,
pubmed-meshheading:7912688-Hepatitis B virus,
pubmed-meshheading:7912688-Humans,
pubmed-meshheading:7912688-Male,
pubmed-meshheading:7912688-Middle Aged,
pubmed-meshheading:7912688-Molecular Sequence Data,
pubmed-meshheading:7912688-Point Mutation,
pubmed-meshheading:7912688-Polymerase Chain Reaction,
pubmed-meshheading:7912688-Polymorphism, Restriction Fragment Length
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pubmed:year |
1994
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pubmed:articleTitle |
Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B.
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pubmed:affiliation |
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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