rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8914
|
pubmed:dateCreated |
1994-7-28
|
pubmed:abstractText |
To investigate an apoptotic role for bcl-2 in menses, we studied bcl-2 protein production throughout the cycle. Bcl-2 protein was observed in endometrial glandular, stromal and myometrial smooth-muscle cells. Glandular cells expressed bcl-2 at proliferative through early secretory phases but not at late secretory through menstrual phases. This cyclic expression of bcl-2 gene was similar to that of oestrogen and progesterone receptors. Thus bcl-2 expression in glandular cells may be regulated by ovarian hormones. The disappearance of bcl-2 expression in glandular cells at late secretory phase was consistent with the appearance of apoptotic cells in the same phase.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0140-6736
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
344
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
28-9
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7912299-Apoptosis,
pubmed-meshheading:7912299-Blotting, Western,
pubmed-meshheading:7912299-Endometrium,
pubmed-meshheading:7912299-Female,
pubmed-meshheading:7912299-Gene Expression Regulation,
pubmed-meshheading:7912299-Humans,
pubmed-meshheading:7912299-Immunohistochemistry,
pubmed-meshheading:7912299-Menstrual Cycle,
pubmed-meshheading:7912299-Proto-Oncogene Proteins,
pubmed-meshheading:7912299-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:7912299-Receptors, Estrogen,
pubmed-meshheading:7912299-Receptors, Progesterone
|
pubmed:year |
1994
|
pubmed:articleTitle |
Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle.
|
pubmed:affiliation |
Department of Anatomy and Biology, Osaka Medical College, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|