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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-7-28
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pubmed:abstractText |
The present studies were conducted to determine whether [3H]quinuclidinyl benzilate binding in rat colonic membranes and/or carbachol-mediated stimulation of particulate guanylate cyclase were altered by changes in vitamin D status. EC50 values for the stimulation of colonic guanylate cyclase by carbachol were found to be significantly greater in vitamin D-deficient rats compared to their D-sufficient counterparts. Concomitantly, the density of receptors (Bmax) were significantly lower, and dissociation constants (Kd) were significantly higher in D-deficient colonic membranes. In vitamin D-repleted animals, moreover, all of these aforementioned alterations were at least partially corrected.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-diphenylacetoxy-1,1-dimethylpiperi...,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Diamines,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Parasympatholytics,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pirenzepine,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidinyl Benzilate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin D,
http://linkedlifedata.com/resource/pubmed/chemical/methoctramine
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
347
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-30
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7912205-Animals,
pubmed-meshheading:7912205-Atropine,
pubmed-meshheading:7912205-Colon,
pubmed-meshheading:7912205-Diamines,
pubmed-meshheading:7912205-Enzyme Activation,
pubmed-meshheading:7912205-Guanylate Cyclase,
pubmed-meshheading:7912205-Male,
pubmed-meshheading:7912205-Muscarinic Antagonists,
pubmed-meshheading:7912205-Nutritional Status,
pubmed-meshheading:7912205-Parasympatholytics,
pubmed-meshheading:7912205-Piperidines,
pubmed-meshheading:7912205-Pirenzepine,
pubmed-meshheading:7912205-Quinuclidinyl Benzilate,
pubmed-meshheading:7912205-Rats,
pubmed-meshheading:7912205-Rats, Sprague-Dawley,
pubmed-meshheading:7912205-Receptors, Muscarinic,
pubmed-meshheading:7912205-Vitamin D
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pubmed:year |
1994
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pubmed:articleTitle |
Vitamin D status modulates rat colonic M3 muscarinic receptor characteristics and coupling to guanylate cyclase.
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pubmed:affiliation |
Department of Medicine, University of Chicago, Hospitals and Clinics, IL 60637.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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