Linked Life Data

7912019

Source:http://linkedlifedata.com/resource/pubmed/id/7912019

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-7-19
pubmed:abstractText
Five female Holstein-Friesian calves were clinically suspected of suffering from Bovine Leukocyte Adhesion Deficiency (BLAD), because of multiple recurrent infections and persistent leucocytosis. The diagnosis was established by a Polymerase Chain Reaction (PCR) technique, by which a point mutation in the DNA encoding for the CD18 allele was detected. The animals either died spontaneously or were killed because of incurable life threatening infections. Gross post-mortem examination revealed severe and extensive necrotizing processes mainly located in the respiratory and digestive tract. Microscopic examination of these necrotizing lesions demonstrated a lack of extravascularly located polymorphonuclear granulocytes (PMN) although vascular leucocytosis was obvious. However, extensive catarrhal bronchopneumonia was noticed with marked infiltration of the alveoli and bronchioli by PMN. These findings are discussed in relation to the pathogenesis of BLAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0165-2176
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Post-mortem findings in calves suffering from bovine leukocyte adhesion deficiency (BLAD).
pubmed:affiliation
Department of Pathology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
pubmed:publicationType
Journal Article