| pubmed-article:7911989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0006849 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C1511649 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:7911989 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:7911989 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7911989 | pubmed:dateCreated | 1994-7-18 | lld:pubmed |
| pubmed-article:7911989 | pubmed:abstractText | We used an experimental model of oral candidiasis in the mouse to investigate the impact of the introduction of Candida albicans into a Candida-free system. We report that 2 strains of mice with the same major histocompatibility complex haplotype (H-2d) display different kinetics of primary oral infection after topical application of the same inoculum. The mucosal reactions in both DBA/2 and BALB/c mice involve a similar recruitment of CD4+ and CD8+ T cells and of MAC-1+ cells in mucosal tissue during the infection. A carrier state is maintained following the resolution of the infection in both strains and is associated with the persistence of intraepithelial CD4+ T cells. However, there is a time-specific recruitment of gamma delta T cells that coincides with a dramatic decrease in viable Candida in the mucosal tissue; this occurs on day 3 in BALB/c mice and on day 6 in DBA/2 mice. The denouement of an oral contact with Candida is also different in the 2 mouse strains, cell-mediated immunity being triggered in DBA/2 mice but not in BALB/c mice. The different kinetics of Candida clearance in BALB/c vs DBA/2 mice may therefore signal a differential priming of T cell subsets whose modalities do not appear to be associated with the H-2 complex. | lld:pubmed |
| pubmed-article:7911989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7911989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911989 | pubmed:citationSubset | D | lld:pubmed |
| pubmed-article:7911989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7911989 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7911989 | pubmed:issn | 0902-0055 | lld:pubmed |
| pubmed-article:7911989 | pubmed:author | pubmed-author:CôtéLL | lld:pubmed |
| pubmed-article:7911989 | pubmed:author | pubmed-author:DeslauriersNN | lld:pubmed |
| pubmed-article:7911989 | pubmed:author | pubmed-author:ChakirJJ | lld:pubmed |
| pubmed-article:7911989 | pubmed:author | pubmed-author:CoulombeCC | lld:pubmed |
| pubmed-article:7911989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7911989 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:7911989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7911989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7911989 | pubmed:pagination | 88-94 | lld:pubmed |
| pubmed-article:7911989 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7911989 | pubmed:meshHeading | pubmed-meshheading:7911989-... | lld:pubmed |
| pubmed-article:7911989 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7911989 | pubmed:articleTitle | Differential pattern of infection and immune response during experimental oral candidiasis in BALB/c and DBA/2 (H-2d) mice. | lld:pubmed |
| pubmed-article:7911989 | pubmed:affiliation | Groupe de Recherche en Ecologie Buccale (GREB), Université Laval, Québec, Canada. | lld:pubmed |
| pubmed-article:7911989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7911989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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