Linked Life Data

7910669

Source:http://linkedlifedata.com/resource/pubmed/id/7910669

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-6-23
pubmed:abstractText
If the sciatic nerve is crushed in neonatal rats, a large proportion of motoneurons die, but the same injury inflicted at five days of age results in little, if any, motoneuron death. However, these motoneurons are rendered susceptible to the excitotoxic effects of the glutamate agonist, N-methyl-D-aspartate. Retrograde labelling of soleus motoneurons after nerve crush at five days of age, followed by treatment with N-methyl-D-aspartate seven days later, shows that only 36 +/- 7.5% of motoneurons have survived. If the motoneurons are allowed to reinnervate their target, and N-methyl-D-aspartate is applied three weeks after the nerve injury, no motoneuron death is observed. Furthermore, adult motoneurons remain resistant to the toxic effects of N-methyl-D-aspartate, even after nerve injury. These results indicate that glutamate, the main excitatory neurotransmitter in the developing spinal cord, may be involved in the motoneuron death that occurs following nerve injury during early postnatal development.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
727-33
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Nerve injury increases the susceptibility of motoneurons to N-methyl-D-aspartate-induced neurotoxicity in the developing rat.
pubmed:affiliation
Department of Anatomy and Developmental Biology, University College, London, U.K.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't