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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6477
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pubmed:dateCreated |
1994-6-14
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pubmed:abstractText |
Complete enzymatic replication of DNA from the simian virus 40 origin has been reconstituted with T antigen and highly purified cellular proteins. DNA polymerase-alpha/primase functions primarily to synthesize RNA-DNA primers for initiation of DNA replication at the origin and for priming each Okazaki fragment. A polymerase switching mechanism requiring replication factor C and the proliferating cell nuclear antigen allows two molecules of DNA polymerase-delta to replicate both strands of the double helix conjointly.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BCL2-related protein A1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed DNA Polymerase,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MATA1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proliferating Cell Nuclear Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RPA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Replication Protein A,
http://linkedlifedata.com/resource/pubmed/chemical/Replication Protein C,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
369
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7910375-Animals,
pubmed-meshheading:7910375-Cattle,
pubmed-meshheading:7910375-DNA, Viral,
pubmed-meshheading:7910375-DNA Replication,
pubmed-meshheading:7910375-DNA-Binding Proteins,
pubmed-meshheading:7910375-DNA-Directed DNA Polymerase,
pubmed-meshheading:7910375-Homeodomain Proteins,
pubmed-meshheading:7910375-Humans,
pubmed-meshheading:7910375-Nuclear Proteins,
pubmed-meshheading:7910375-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:7910375-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:7910375-Replication Protein A,
pubmed-meshheading:7910375-Replication Protein C,
pubmed-meshheading:7910375-Repressor Proteins,
pubmed-meshheading:7910375-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:7910375-Simian virus 40,
pubmed-meshheading:7910375-Templates, Genetic,
pubmed-meshheading:7910375-Viral Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro.
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pubmed:affiliation |
Cold Spring Harbor Laboratory, New York 11724.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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