| pubmed-article:7910125 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7910125 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:7910125 | lifeskim:mentions | umls-concept:C0063695 | lld:lifeskim |
| pubmed-article:7910125 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:7910125 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7910125 | pubmed:dateCreated | 1994-6-16 | lld:pubmed |
| pubmed-article:7910125 | pubmed:abstractText | The objective of this study is to determine whether soluble intercellular adhesion molecule-1 (sICAM-1) is found in rheumatoid arthritis (RA) and other inflammatory disorders and to identify which cells are responsible for sICAM-1 production. Synovial fluid, blood and cells isolated from RA synovial fluids, and synovial tissues from 59 patients were studied. In addition, normal peripheral blood was obtained. sICAM-1 was assayed by an enzyme-linked immunoabsorbent assay. Synovial fluids from patients with RA and other inflammatory arthritides had significantly higher sICAM-1 levels than did osteoarthritis (OA) synovial fluids. Synovial fluid sICAM-1 levels were significantly positively correlated with synovial fluid leukocyte counts. RA synovial tissue fibroblasts released low levels of sICAM-1. Neutrophils (PMNs) isolated from synovial fluids of RA patients spontaneously released sICAM-1. However, mononuclear cells isolated from RA synovial fluid produced the largest quantities of sICAM-1. Phytohemagglutinin but not lipopolysaccharide enhanced mononuclear sICAM-1 release. sICAM-1 was increased in synovial fluids from RA compared to OA. This sICAM-1 may be important in modulating the trafficking of inflammatory leukocytes into diseased RA synovial tissue and fluid. | lld:pubmed |
| pubmed-article:7910125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7910125 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7910125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7910125 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7910125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7910125 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7910125 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7910125 | pubmed:month | May | lld:pubmed |
| pubmed-article:7910125 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:7910125 | pubmed:author | pubmed-author:PopeR MRM | lld:pubmed |
| pubmed-article:7910125 | pubmed:author | pubmed-author:KochA EAE | lld:pubmed |
| pubmed-article:7910125 | pubmed:author | pubmed-author:HarlowL ALA | lld:pubmed |
| pubmed-article:7910125 | pubmed:author | pubmed-author:LovisR MRM | lld:pubmed |
| pubmed-article:7910125 | pubmed:author | pubmed-author:ShahM RMR | lld:pubmed |
| pubmed-article:7910125 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7910125 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:7910125 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7910125 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7910125 | pubmed:pagination | 208-15 | lld:pubmed |
| pubmed-article:7910125 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:meshHeading | pubmed-meshheading:7910125-... | lld:pubmed |
| pubmed-article:7910125 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7910125 | pubmed:articleTitle | Soluble intercellular adhesion molecule-1 in arthritis. | lld:pubmed |
| pubmed-article:7910125 | pubmed:affiliation | Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611. | lld:pubmed |
| pubmed-article:7910125 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7910125 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7910125 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7910125 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7910125 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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