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pubmed:abstractText |
The dopamine (DA) receptor mediating the inhibitory effect of light on melatonin formation in the chick retina was characterized pharmacologically. Nighttime serotonin N-acetyltransferase (NAT) activity was significantly decreased by either light exposure or by intraocular (i.oc.) administration of DA and quinpirole (a predominant D3/D4 DA receptor agonist). Several D2-like DA receptor antagonists, i.e. clozapine, haloperidol, spiroperidol, sulpiride, (+)-UH-232 and YM-09151-2, given i.oc. to light-adapted chicks markedly elevated retinal NAT activity. In contrast, raclopride (a D2/D3 DA receptor antagonist) and remoxipride (a D2-selective DA receptor antagonist) were ineffective. Spiroperidol, clozapine, haloperidol and sulpiride significantly increased melatonin content in the light-exposed retina, but had no effect on the activity of hydroxyindole-O-methyltransferase. None of D2-like DA receptor blockers tested modified the nighttime NAT activity in the chick retina. Our results indicate that the light-evoked inhibition of the nocturnal increase in melatonin biosynthesis in chick retina may involve stimulation of the D4 subtype DA receptor.
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