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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1994-6-1
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pubmed:abstractText |
Antigen-induced activation of T cells can be specifically inhibited by antigen analogs that have been termed T-cell receptor peptide antagonists. These antagonists appear to act by inducing the formation of nonstimulatory or partially stimulatory complexes between T-cell receptors and the major histocompatibility complex molecules presenting the peptides. Herein, we have investigated the effect of T-cell receptor peptide antagonists on thymocyte negative selection. First, peptide antagonists were identified for the cytochrome c-specific T-cell clone AD10. These peptides were then tested for their ability to induce negative selection in an in vitro model system using thymocytes from mice transgenic for the AD10 T-cell receptor. Though unable to induce mature T-cell activation, the T-cell receptor peptide antagonists induced deletion of CD4+ CD8+ thymocytes. These results suggest that negative selection of CD4+ CD8+ thymocytes can be induced by T-cell receptor interactions of a lower affinity than those required for mature T-cell activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1309938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1314886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1315417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1316916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1409596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1671358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1688589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1710780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1730877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1739971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1763329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-1903182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2188673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2442249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2553848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2783386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2832942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-2863322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-3877245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-6181895,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-6208128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-6271869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-6412230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-7688388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8124708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8384651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8417115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8464874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8483498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7909610-8496675
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
26
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4057-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7909610-Animals,
pubmed-meshheading:7909610-Antigens, CD8,
pubmed-meshheading:7909610-Base Sequence,
pubmed-meshheading:7909610-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7909610-Clonal Deletion,
pubmed-meshheading:7909610-Lymphocyte Activation,
pubmed-meshheading:7909610-Mice,
pubmed-meshheading:7909610-Mice, Transgenic,
pubmed-meshheading:7909610-Molecular Sequence Data,
pubmed-meshheading:7909610-Peptides,
pubmed-meshheading:7909610-Receptors, Antigen, T-Cell,
pubmed-meshheading:7909610-T-Lymphocyte Subsets,
pubmed-meshheading:7909610-Thymus Gland
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pubmed:year |
1994
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pubmed:articleTitle |
Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.
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pubmed:affiliation |
Department of Biology, University of California at San Diego, La Jolla 92093-0063.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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