Linked Life Data

7908452

Source:http://linkedlifedata.com/resource/pubmed/id/7908452

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-5-4
pubmed:abstractText
The major T lymphocyte subpopulations expressing CD8, CD4, or antigen-specific T cell receptor (TCR) heterodimer alpha beta (TCR2) or gamma delta (TCR1) were assessed in duodenum intraepithelium of two inbred chicken strains, SC and TK, by single- and double-label immunofluorescence (IF) at various times after oral inoculation with Eimeria acervulina. The duodenum intraepithelial T lymphocytes (IEL) expressing the CD8 antigen (cytotoxic/suppressor T cells) increased in the SC and TK chickens following primary infection. However, a significant increase in the duodenum CD8+ IEL occurred in the SC chickens which manifested as a lower level of oocyst production compared to the TK chickens following primary and challenge infections. The CD4+ (T helper) cells increased seven days after primary infection in SC and TK chickens, and in TK chickens seven days after challenge infection. Two colour immunofluorescence analysis of duodenum IEL at 10 days after challenge infection revealed that the majority of CD8+ IEL expressed the TCR2 antigen. Furthermore, the SC chickens showed increased TCR2+CD8+ cells shortly following challenge with E acervulina. These results suggest that variations in T cell subpopulations may reflect eimerian infection-related changes in the gut-associated lymphoid tissues and that a significant increase in CD8+ IEL in SC chickens may reflect enhanced acquired immune status in SC chickens compared to TK chickens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0034-5288
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Analysis of Eimeria acervulina-induced changes in the intestinal T lymphocyte subpopulations in two chicken strains showing different levels of susceptibility to coccidiosis.
pubmed:affiliation
Protozoan Diseases Laboratory, Beltsville Agricultural Research Center East, US Department of Agriculture, Maryland 20705.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.