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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-4-8
|
| pubmed:databankReference | |
| pubmed:abstractText |
The activity of the C. elegans gene ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of this gene. ced-9 is an element of a polycistronic locus that also contains the gene cyt-1, which encodes a protein similar to cytochrome b560 of complex II of the mitochondrial respiratory chain. ced-9 encodes a 280 amino acid protein showing sequence and structural similarities to the mammalian proto-oncogene bcl-2. Overexpression of bcl-2 can mimic the protective effect of ced-9 on C. elegans cell death and can prevent the ectopic cell deaths that occur in ced-9 loss-of-function mutants. These results suggest that ced-9 and bcl-2 are homologs and that the molecular mechanism of programmed cell death has been conserved from nematodes to mammals.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
76
|
| pubmed:geneSymbol |
A1,
Bax &agr;,
Bcl-xL,
MCL1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
665-76
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7907274-Amino Acid Sequence,
pubmed-meshheading:7907274-Animals,
pubmed-meshheading:7907274-Animals, Genetically Modified,
pubmed-meshheading:7907274-Apoptosis,
pubmed-meshheading:7907274-Base Sequence,
pubmed-meshheading:7907274-Caenorhabditis,
pubmed-meshheading:7907274-Caenorhabditis elegans,
pubmed-meshheading:7907274-Cell Survival,
pubmed-meshheading:7907274-Cloning, Molecular,
pubmed-meshheading:7907274-Consensus Sequence,
pubmed-meshheading:7907274-DNA Primers,
pubmed-meshheading:7907274-Gene Expression,
pubmed-meshheading:7907274-Genes, Helminth,
pubmed-meshheading:7907274-Molecular Sequence Data,
pubmed-meshheading:7907274-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:7907274-Proto-Oncogene Proteins,
pubmed-meshheading:7907274-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:7907274-RNA, Messenger,
pubmed-meshheading:7907274-Restriction Mapping,
pubmed-meshheading:7907274-Sequence Alignment,
pubmed-meshheading:7907274-Sequence Homology, Amino Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2.
|
| pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|