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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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|
pubmed:dateCreated |
1994-3-29
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|
pubmed:abstractText |
We report that certain oligonucleotides are capable of inhibiting cell surface induction of the major histocompatibility complex class I (MHC-I) proteins by interferon-gamma in K562 cells. The inhibition by oligodeoxy-nucleotide I 5' GGG GTT GGT TGT GTT GGG TGT TGT GT-RNH2 is dose-dependent, with an EC50 24 hr after dosing of approximately 4 microM for 800 U/ml interferon-gamma. The reverse complement II 5' AC ACA ACA CCC AAC ACA ACC AAC CCC-RNH2 did not show activity. Oligodeoxynucleotide I inhibits induction of MHC-I by interferon-gamma, but does not inhibit induction by either interferon-alpha or interferon-beta. Four other oligodeoxynucleotides were also evaluated, and three showed activity against interferon-gamma at 25 microM.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
|
pubmed:issn |
0041-1337
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|
pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
27
|
|
pubmed:volume |
57
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
612-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7906905-Base Sequence,
pubmed-meshheading:7906905-Cell Adhesion Molecules,
pubmed-meshheading:7906905-Cell Line,
pubmed-meshheading:7906905-Gene Expression,
pubmed-meshheading:7906905-Genes, MHC Class I,
pubmed-meshheading:7906905-Histocompatibility Antigens Class I,
pubmed-meshheading:7906905-Humans,
pubmed-meshheading:7906905-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7906905-Interferon-gamma,
pubmed-meshheading:7906905-Molecular Sequence Data,
pubmed-meshheading:7906905-Oligodeoxyribonucleotides,
pubmed-meshheading:7906905-Promoter Regions, Genetic,
pubmed-meshheading:7906905-RNA, Messenger,
pubmed-meshheading:7906905-Receptors, Transferrin
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pubmed:year |
1994
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|
pubmed:articleTitle |
Inhibition of interferon-gamma-induced major histocompatibility complex class I expression by certain oligodeoxynucleotides.
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pubmed:affiliation |
University of California, San Francisco, California.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
