Linked Life Data

7906301

Source:http://linkedlifedata.com/resource/pubmed/id/7906301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-3-24
pubmed:abstractText
Human immunodeficiency virus (HIV)-induced destruction of follicular dendritic cells (FDCs), which are important in immunological memory, may be a major pathway of HIV pathogenesis. We use a mathematical model to investigate this hypothesis and conclude that a low level of FDC destruction could ultimately result in loss of control of HIV. Their slow turnover makes them good candidates for the part of the immune system that fails during the long period of HIV infection. As FDC destruction is essentially a misdirected immune response, too much immunotherapy may be detrimental. Our model shows how to estimate this critical level of immunotherapy. We derive an expression for the time taken to the loss of immune control. Transient changes in the viral growth rate before the immune system fails do not affect this time, providing a possible explanation for the results of the Concorde trial. We suggest that inducible B cell function is a good potential marker of disease progression, indicating the functional ability of the FDC network. Finally, we rereview data in the light of the FDC theory, paying particular attention to data on CD4+ numbers and function that are inconsistent with the classical view of HIV pathogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0894-9255
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-44
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Germinal centre destruction as a major pathway of HIV pathogenesis.
pubmed:affiliation
Department of Zoology, University of Oxford, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't