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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1994-3-22
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pubmed:abstractText |
During inflammation in the skin keratinocytes can express major histocompatibility complex class II molecules but are unable to present nominal antigens to resting T cells. Certain bacteria including staphylococci produce a new class of antigens termed superantigens that are very potent T-cell activators. Using an in vitro model with cultured normal human keratinocytes and purified allogeneic T cells, we demonstrated that major histocompatibility complex class II+ keratinocytes can activate T cells in the presence of the superantigen staphylococcal enterotoxin B. Major histocompatibility complex class II+ keratinocytes activated T cells at concentrations of staphylococcal enterotoxin B as low as 100 pg/ml. The activation required contact between keratinocytes and T cells, was inhibited with a monoclonal antibody to human leukocyte antigen DR, -DQ, and was not affected by fixation of the keratinocytes. These data show that major histocompatibility complex class II+ keratinocytes activate T cells in the presence of the superantigen staphylococcal enterotoxin B.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DQ Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Superantigens,
http://linkedlifedata.com/resource/pubmed/chemical/enterotoxin B, staphylococcal
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-202X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-4
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7906285-Antibodies, Monoclonal,
pubmed-meshheading:7906285-Cell Adhesion Molecules,
pubmed-meshheading:7906285-Cell Division,
pubmed-meshheading:7906285-Cells, Cultured,
pubmed-meshheading:7906285-Dose-Response Relationship, Drug,
pubmed-meshheading:7906285-Enterotoxins,
pubmed-meshheading:7906285-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7906285-HLA-DQ Antigens,
pubmed-meshheading:7906285-HLA-DR Antigens,
pubmed-meshheading:7906285-Histocompatibility Antigens Class II,
pubmed-meshheading:7906285-Humans,
pubmed-meshheading:7906285-Intercellular Adhesion Molecule-1,
pubmed-meshheading:7906285-Interferon-gamma,
pubmed-meshheading:7906285-Keratinocytes,
pubmed-meshheading:7906285-Lymphocyte Activation,
pubmed-meshheading:7906285-Staphylococcus,
pubmed-meshheading:7906285-Superantigens,
pubmed-meshheading:7906285-T-Lymphocytes
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pubmed:year |
1994
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pubmed:articleTitle |
Interferon gamma-treated keratinocytes activate T cells in the presence of superantigens: involvement of major histocompatibility complex class II molecules.
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pubmed:affiliation |
Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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