Linked Life Data

7905281

Source:http://linkedlifedata.com/resource/pubmed/id/7905281

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1994-3-7
pubmed:abstractText
We have studied by immunohistofluorescence and confocal microscopy the localization of the XlHbox-1 protein, the product of a Xenopus class 1 homeobox gene corresponding to the human HOX 3C, during the development of Xenopus laevis mesodermal derivatives. The protein, not present at early stages of embryonic development, can first be detected in the neurula where it is weakly expressed in the rostral part of the spinal cord and in the nuclei of the corresponding somites. At later stages of mesodermal development, very high levels of the molecule are present in the nuclei of a small group of myogenic cells in the most dorsal aspect of the myotome, while the nuclei of differentiated muscle fibers within the myotome are either stained weakly or completely negative. A similar transient expression of XlHbox-1 gene product during myogenesis occurs during muscle differentiation in the limb bud and during differentiation of visceral smooth muscles from the lateral plate mesoderm. In both cases the nuclei of precursor cells contain high level of this protein which is rapidly down regulated during further muscle differentiation. In myogenic areas the modulation of XlHbox-1 expression invariably parallels that of the neural cell adhesion molecule N-CAM. These data are the first evidence that a homeobox gene belonging to the Antennapedia-Bithorax complex is transiently expressed in early phases of muscle differentiation. The transient expression of homeobox genes in early phases of embryonic development could act synergistically with the expression of other myogenic transcriptional factors to specify a fine level of differentiation of the muscle cells along the body axis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0925-4773
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:geneSymbol
HOX 3C, Hox 3.3, XlHbox-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Changes in the prevalence of an homeobox gene product during muscle differentiation.
pubmed:affiliation
Laboratoire du Physiopathologie du Developpement, C.N.R.S. URA 1337, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't