Linked Life Data

7904974

Source:http://linkedlifedata.com/resource/pubmed/id/7904974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-3-1
pubmed:databankReference
pubmed:abstractText
The human erbB-2 gene encodes a receptor protein tyrosine kinase which has strong growth-promoting properties. Overexpression of erbB-2 is directly associated with tumor cell growth in vivo and in vitro. To investigate structural features which may contribute to expression, we isolated and sequenced a 3.65-kb 5' promoter fragment of the human erbB-2 gene. This 5' fragment contains an exceptionally high density of four Alu sequences. Other structural features include an A + T-rich region that causes DNA bending, as measured by anomalously slow migration in polyacrylamide gels. These structural features of the 5' region of erbB-2 may contribute to expression of the gene in different growth states.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
136
pubmed:geneSymbol
erbB-2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
361-4
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Structural features of the 5' region of the human erbB-2 gene.
pubmed:affiliation
Department of Medicine, University of California San Diego, La Jolla 92093-0650.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't