Linked Life Data

790496

Source:http://linkedlifedata.com/resource/pubmed/id/790496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1976-12-23
pubmed:abstractText
The effect of heparin of therapeutic dose on the basal insulin secretion and on that of induced by glucose stimulation was studied in dogs and in Langerhans islets in vitro model. The effect of heparin, given intraarterially (a. pancreaticoduodenalis sup.) and injected i.v. before i.v. glucose load, on the immuno-reactive insulin concentration of the pancreatic and peripheral venous blood as well as the blood sugar and free fatty acid levels of the peripheral venous blood was investigated. Heparin inhibited significantly both the basal insulin secretion and that of following glucose stimulation. After the injection of heparin the glucose assimilation coefficient decreased significantly. The inhibitory effect of heparin on the basal insulin secretion and the glucose stimulated insulin secretion was observed in Langerhans islets in vitro model, too. This suggests that heparin, at least partly, inhibits insulin secretion directly through its influence on the beta cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0300-9130
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
167
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
239-54
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Effect of heparin on insulin secretion in vivo and in vitro.
pubmed:publicationType
Journal Article, In Vitro