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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-3-2
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pubmed:abstractText |
The ability of N-methyl-D-aspartate (NMDA) receptor agonists and antagonists to modify 3-nitropropionic acid toxicity was studied in cultured rat cerebellar granule neurons. Exposure of these neurons to 3-nitropropionic acid resulted in a concentration and time-dependent neurotoxicity. In contrast to glutamate toxicity, 3-nitropropionic acid toxicity was potentiated by preexposure to subtoxic concentrations of NMDA. Presumably, the 3-nitropropionic acid-induced energy depletion relieved the voltage-dependent Mg2+ block of the NMDA receptor and induced vulnerability to subtoxic concentrations of NMDA receptor agonists. MK-801 and 2-amino-5-phosphonovaleric acid (APV) delayed but did not prevent 3-nitropropionic acid toxicity, indicating that prolonged exposure to 3-nitropropionic acid ultimately resulted in histotoxic neuronal death. We conclude that there are at least two distinct mechanisms of 3-nitropropionic acid toxicity of cerebellar granule neurons, one indirectly involving NMDA receptor-mediated excitotoxicity and one that is NMDA receptor-independent.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
248
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
223-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:7904944-2-Amino-5-phosphonovalerate,
pubmed-meshheading:7904944-Animals,
pubmed-meshheading:7904944-Cells, Cultured,
pubmed-meshheading:7904944-Cerebellum,
pubmed-meshheading:7904944-Cytoplasmic Granules,
pubmed-meshheading:7904944-Dizocilpine Maleate,
pubmed-meshheading:7904944-Electrophysiology,
pubmed-meshheading:7904944-Glutamates,
pubmed-meshheading:7904944-Glutamic Acid,
pubmed-meshheading:7904944-Neurons,
pubmed-meshheading:7904944-Neurotoxins,
pubmed-meshheading:7904944-Nitro Compounds,
pubmed-meshheading:7904944-Propionic Acids,
pubmed-meshheading:7904944-Rats,
pubmed-meshheading:7904944-Rats, Sprague-Dawley,
pubmed-meshheading:7904944-Receptors, N-Methyl-D-Aspartate
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pubmed:year |
1993
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pubmed:articleTitle |
3-Nitropropionic acid is an indirect excitotoxin to cultured cerebellar granule neurons.
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pubmed:affiliation |
Section on Molecular Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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