Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-3-1
pubmed:abstractText
The identification and molecular characterization of Brn-3.2 has revealed a family of Brn-3-related mammalian POU proteins that share homology with the C. elegans developmental regulator Unc-86 and extended similarity with the Drosophila neurodevelopmental gene I-POU, which defines a novel POU-IV box. Brn-3.2 exhibits DNA binding properties similar to those of Brn-3.0, but its expression is uniquely regulated by retinoic acid in teratocarcinoma and neuroblastoma cells. In the developing PNS and retina, the expression pattern of Brn-3.2 is similar to that of Brn-3.0. In the caudal CNS (spinal cord, hindbrain, and midbrain) Brn-3.2 and Brn-3.0 are initially coexpressed, but diverge later in development. Rostral to the midbrain, Brn-3.2 and Brn-3.0 exhibit nonoverlapping patterns of expression, suggesting divergence of gene function in more recently evolved structures. Our analysis suggests that in the CNS Brn-3.2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:geneSymbol
Brn-3.0, Brn-3.2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-18
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:7904822-Amino Acid Sequence, pubmed-meshheading:7904822-Animals, pubmed-meshheading:7904822-Base Sequence, pubmed-meshheading:7904822-Brain, pubmed-meshheading:7904822-Cell Differentiation, pubmed-meshheading:7904822-Cell Line, pubmed-meshheading:7904822-DNA, Complementary, pubmed-meshheading:7904822-DNA-Binding Proteins, pubmed-meshheading:7904822-Drosophila, pubmed-meshheading:7904822-Embryo, Mammalian, pubmed-meshheading:7904822-Embryo, Nonmammalian, pubmed-meshheading:7904822-Gene Expression, pubmed-meshheading:7904822-Gene Expression Regulation, pubmed-meshheading:7904822-Gene Library, pubmed-meshheading:7904822-Genes, Homeobox, pubmed-meshheading:7904822-Homeodomain Proteins, pubmed-meshheading:7904822-In Situ Hybridization, pubmed-meshheading:7904822-Mesencephalon, pubmed-meshheading:7904822-Mice, pubmed-meshheading:7904822-Mitosis, pubmed-meshheading:7904822-Molecular Sequence Data, pubmed-meshheading:7904822-Neuroblastoma, pubmed-meshheading:7904822-Neurons, pubmed-meshheading:7904822-Organ Specificity, pubmed-meshheading:7904822-Rhombencephalon, pubmed-meshheading:7904822-Sequence Homology, Amino Acid, pubmed-meshheading:7904822-Spinal Cord, pubmed-meshheading:7904822-Teratoma, pubmed-meshheading:7904822-Transcription Factor Brn-3, pubmed-meshheading:7904822-Transcription Factor Brn-3A, pubmed-meshheading:7904822-Transcription Factor Brn-3B, pubmed-meshheading:7904822-Transcription Factors, pubmed-meshheading:7904822-Transfection, pubmed-meshheading:7904822-Tretinoin, pubmed-meshheading:7904822-Tumor Cells, Cultured
pubmed:year
1994
pubmed:articleTitle
Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid.
pubmed:affiliation
Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't